side effects of evening primrose oil

2005;3(1):7-10. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Hederos CA, Berg A. Epogam evening primrose oil treatment in atopic dermatitis and asthma. Vaddadi KS. Rose DP, Connolly JM, Liu XH. Puri BK. Martens-Lobenhoffer, J. and Meyer, F. P. Pharmacokinetic data of gamma-linolenic acid in healthy volunteers after the administration of evening primrose oil (Epogam). Br Med Bull. View abstract. View abstract. J Nutr 2003;133(11 Suppl 1):3785S-3793S. View abstract. Prostaglandins Leukot.Essent.Fatty Acids 1999;60(3):199-208. Supplement manufacturers claim that it may reduce fatigue, clear acne, promote weight loss and improve asthma symptoms. Morse PF, Horrobin DF, Manku MS, et al. 2012;3, Centre for Reviews and Dissemination. J Hypertens 1992;10:1197-204. 1994;4(598):603. Liang XC and Guo SS. 2003;16(1):47-57. 2004;38(4):386-395. View abstract. When taken in appropriate amounts short term, oral use of evening primrose oil is most likely safe.Evening primrose oil can cause: 1. Research evaluating evening primrose for schizophrenia shows conflicting results. 2012;27(3):16-17. Aspirin, for example, may put you at risk for stomach ulcers, hemorrhagic stroke and allergic reactions, warns the Mayo Clinic. However, other studies using up to 6 grams daily for up to 4 menstrual cycles found no benefit. 2012;7(2):273-280. The Women's Healthy Eating and Living Study Group. Prostaglandins Leukot.Essent.Fatty Acids 1993;49(4):809-814. Takwale A, Tan E, Agarwal S, et al. J Dev Behav Pediatr 2007;28:82-91. Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. Roemheld-Hamm B, Dahl NV. View abstract. View abstract. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). 1993;27(12):1475-1477. Psychiatry Res 1989;27(3):313-323. In: Horrobin DF. G.Clin Med 1987;68(1):23-28. View abstract. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). Placebo-controlled trial of essential fatty acid supplementation in atopic dermatitis. View abstract. Currently, there is no standard treatment for PMS. Hot flashes experienced by women going through the menopause have a number of non-hormonal treatment options, but, according to the evidence, evening primrose oil does not have an effect. Womens Health Issues 1994;4(3):130-137. 8-8-2005;226(1):17-25. Gruenwald, J., Graubaum, H. J., and Busch, R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. Be sure to tell your doctor what natural products you are taking before having surgery. Barabino, S., Rolando, M., Camicione, P., Ravera, G., Zanardi, S., Giuffrida, S., and Calabria, G. Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Blommers J, de Lange-De Klerk ES, Kuik DJ, et al. Horrobin, D. F. and Stewart, C. Evening primrose oil in atopic eczema. Br J Dermatol 1987;117:11-9. View abstract. Br J Clin Pharmacol 1985;19:335-42. Aceite de Onagra, Acide Cis-linoléique, Cis-Linoleic Acid, EPO, Evening Primrose, Evening Primrose Seed Oil, Fever Plant, Herbe-aux-ânes, Huile de Graines d’Onagre, Huile D'Onagre, Huile de Primerose, Huile de Primevère Vespérale, Jambon de Jardinier, Jambon du Paysan, King's Cureall, Mâche Rouge, Night Willow-Herb, Oenothera biennis, Oenothera muricata, Oenothera purpurata, Oenothera rubricaulis, Oenothera suaveolens, Œnothère, Oil of Evening Primrose, Onagra biennis, Onagraire, Onagre Bisannuelle, Onagre Commune, Primevère du Soir, Primrose, Primrose Oil, Scabish, Sun Drop. View abstract. Lancet 1995;345(8963):1463-1468. Scand J Rheumatol 1983;12:85-8. 2002;79(3):195-207. 1988;7(1):S189. With every form of treatment comes the possibility of side effects as every persons reaction system is different. Joint swelling (inflammation) in people with psoriasis. Like most supplements, there hasn't been much research assessing the long-term safety of evening primrose oil. Jamal, G. A., Carmichael, H., and Weir, A. I. Gamma-linolenic acid in diabetic neuropathy. View abstract. Rosolowich, V., Saettler, E., Szuck, B., Lea, R. H., Levesque, P., Weisberg, F., Graham, J., McLeod, L., and Rosolowich, V. Mastalgia. Little is known about the actual benefits of evening primrose oil. Huntley, A. Drug-herb interactions with herbal medicines for menopause. View abstract. Dante, G. and Facchinetti, F. Herbal treatments for alleviating premenstrual symptoms: a systematic review. View abstract. View abstract. Ann Med Psychol (Paris) 1983;141(8):883-891. J Pediatr 2008;152:140, 140.e1. Prostaglandins and premenstrual syndrome. View abstract. Evening primrose oil may cause low blood pressure. View abstract. Engler MM, Engler MB, Erickson SK, Paul SM. Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia cured! 1995;6(4):209-212. Early research shows that taking 18 grams of evening primrose per day does not affect liver size or survival in people with liver cancer. The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. The effect of acute alcohol intoxication in psychometric testing and 5-HT-induced platelet aggregation in normal subjects; modulatory roles of evening primrose oil. View abstract. In some cases, primrose oil may cause side effects such as stomach upset, headache, nausea, and diarrhea.2 Most of the side effects are low-grade and resolve on their own once the treatment is stopped. Rec Adv Clin Nutr 1986;2:404-405. View abstract. View abstract. Wright, S. and Burton, J. L. Oral evening-primrose-seed oil improves atopic eczema. In one study, infants fed this formula had better eyesight than infants fed regular formula, but not better than those who were breastfed. Wetzig, N. R. Mastalgia: a 3 year Australian study. Dr. Ed Friedlander answered. Curr Ther Res 1989;46(1):58-63. Int.J Obes 1983;7(6):549-553. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. Lancet 1985;2:373-7. 2003;139(1):21. The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse Unfortunately, science does not support these claims. Parveen, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of evening primrose in the treatment of mastalgia. Purewal TS, Evans PMS, Havard F, O'Hare JP. J Reprod.Med 1997;42(10):637-646. Am J Obstet Gynecol 2002;187:1389-94.. View abstract. Cheung KL. Int J STD AIDS. Kiss, A. K., Filipek, A., Czerwinska, M., and Naruszewicz, M. Oenothera paradoxa defatted seeds extract and its bioactive component penta-O-galloyl-beta-D-glucose decreased production of reactive oxygen species and inhibited release of leukotriene B4, interleukin-8, elastase, and myeloperoxidase in human neutrophils. Dry eye. View abstract. Altern Med Rev 2010;15(1):59-67. Breast 2007;16(5):503-512. View abstract. (check all that apply), What factors are most important to you? J Nurse Midwifery 1999;44:320-4. Med Monatsschr.Pharm. Int.J Gynaecol.Obstet. Kwon HS, Lee JH, Kim GM, Choi EH, Bae JM. vitamins, herbal supplements, etc. Side Effects of Evening Primrose Oil for Menopause. Med Hypotheses 1979;5(3):365-378. J Fam.Pract. 43 years experience Pathology. HeadacheDon't take evening primrose if you have a bleeding disorder. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 47. Menopause. View abstract. View abstract. Br.J Dermatol. View abstract. Poisson J, Germain-Bellenger S, Engler M, and et al. Kruger, M. C., Coetzer, H., de Winter, R., Gericke, G., and van Papendorp, D. H. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Zhong Xi Yi Jie He Za Zhi 1991;11:20-2, 4. Arzneimittelforschung 2006;56(8):574-581. Clin Rheumatol 1989;8(2):238-244. According to the same source, EPO may cause labor abnormalities. View abstract. Most women use either over-the-counter (OTC) pain relievers or home remedies. 2008;74(5):447-452. Both OTC and prescription drugs have risks. In most studies, taking evening primrose does not reduce hot flashes or night sweats any more than a placebo (sugar pill). The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. Evening primrose oil benefits are said to include everything from PMS relief to better cardiovascular health. View abstract. View abstract. Early research shows that taking evening primrose, 3 grams per day in adults or 2 grams per day in children, does not improve symptoms of ichthyosis. Prevalence and treatment. Goodwin, P. J., Neelam, M., and Boyd, N. F. Cyclical mastopathy: a critical review of therapy. BMJ 2003;327:1358-9. The lipids that matter from infant nutrition to insulin resistance. Anstey, A. Quigley M. Wilkinson J. D. Topical evening primrose oil as treatment for atopic eczema. Horrobin DF. Essential fatty acid supplementation in tardive dyskinesia. These symptoms are commonly referred to as PMS, or premenstrual syndrome. Evening primrose oil: a panacea? Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the Possible side effects of evening primrose oil for weight loss. What factors influenced or will influence your purchase? The problem is that it may interact with certain drugs, including anticoagulants, antidepressants and antihypertensives. View abstract. 2009;19(1):43-46. Z.Hautkr. Allergic reactions are rare but possible. View abstract. Acta Obstet Gynecol.Scand 2005;84(10):972-979. Evening primrose oil and premenstrual syndrome. If you're under medical treatment, ask your health care provider about the safety of evening primrose. Schizophrenia. Hauben, M. Comment: evening primrose oil in the treatment of rheumatoid arthritis-- proper application of statistical analysis. Hanna K, Day A O'Neill S Patterson C Lyons-Wall P. Does scientific evidence support the use of non-prescription supplements for treatment of acute menopausal symptoms such as hot flushes? Early research shows that taking 4 grams per day of evening primrose for 12 months does not improve liver damage in people with hepatitis B. Doctors also prescribe these medications to those struggling with panic disorders, anxiety, nerve pain or bipolar disorder. Aust N Z J Surg 1994;64(5):329-331. J Am Diet Assoc 2000;100:1368-80. Hardy ML. Biol Psychiatry 1989;25:222-8. Laugharne, J. D., Mellor, J. E., and Peet, M. Fatty acids and schizophrenia. Topical gamma-linolenic acid therapy in atopic dermatitis: a clinical and biometric evaluation. Polyunsaturated fatty acid levels in premenstrual syndrome and the effect of dietary supplementation on symptoms. EPO may contribute to pregnancy complications and increased bleeding in people taking warfarin and other blood-thinning drugs. View abstract. ), allergies, pre-existing diseases, and current health conditions (e.g. Acta Neurol Scand 1999;99:112-6. View abstract. Hounsom, L., Horrobin, D. F., Tritschler, H., Corder, R., and Tomlinson, D. R. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Ann Allergy 1989;62(6):534-537. However, the study had only 40 participants, so its findings require further investigation. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Before taking evening primrose oil, or any other supplement, talk to your doctor about potential risks and drug interactions. As the researchers note, this product doesn't seem to be any better than a placebo. Lancet 4-7-1990;335(8693):864-865. Ernst, E. and Chrubasik, S. Phyto-anti-inflammatories. View abstract. View abstract. Belch JJ, Ansell D, Madhok R, et al. Manchester, England, April 1991. pg 89-96. Evening primrose oil may increase the risk of bleeding in people wi… Studies show that it may also pose risks during pregancy or … This survey is being conducted by the WebMD marketing sciences department. Lack of effect of evening primrose oil on autonomic function tests after 12 months of treatment. Lancet 1993;341:1557-60. Gimenes, O. M., da Silva, M. J., and Benko, M. A. View abstract. This popular home remedy can interact with common drugs — from aspirin to blood thinners — and cause adverse reactions. Ann Pharmacother 2004;38(9):1482-1499. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. O'Brien PM, Morrison R, Pipken FB. Part 2: Rheumatoid arthritis. Jaszewska, E., Kosmider, A., Kiss, A. K., and Naruszewicz, M. Oenothera paradoxa defatted seeds extract containing pentagalloylglucose and procyanidins potentiates the cytotoxicity of vincristine. Dietary supplementation with primrose oil or fish oil does not change urinary excretion of prostacyclin and thromboxane metabolites in pre-eclamptic women. The risks are even greater for pregnant women who use this remedy to reduce labor time. View abstract. Jellin JM, Batz F Hitchens K. Pharmacists letter/Prescriber's letter; Natural Comprehensive Database. The most common side effects are temporary gastrointestinal symptoms such as abdominal pain, fullness, or nausea. J Reprod.Med 1983;28(7):465-468. Taking evening primrose, up to 4 grams daily for 4-6 weeks, doesn't seem to improve ADHD symptoms in children. 2000;(2):CD001257. Endres, S., Lorenz, R., and Loeschke, K. Lipid treatment of inflammatory bowel disease. Skogh, M. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma- linolenic acids). Lancet 5-10-1986;1(8489):1098. Massil H, Brush M, Manku M, and et al. Clin Obstet.Gynecol. Lancet 11-20-1982;2(8308):1120-1122. Makrides M, Neumann M, Simmer K, Pater J, and Gibson R. Are long-chain polyunsaturated fatty acids essential nutrients in infancy? View abstract. Diabet Med 1990;7(4):319-323. , View abstract. View abstract. Gateley, C. A. and Mansel, R. E. Management of the painful and nodular breast. 2020;34(10):2628-2638. Br J Psychiatry 1999;175:88. View abstract. Evening primrose oil (EPO) has been used as a PMS remedy for centuries. Evening primrose oil or other omega-6 fatty acids should be avoided by anyone who suffers a seizure disorder or bleeding problems. 2018 Feb;43(1):1-10. 2011;(2):CD002948. A motor skill disorder marked by clumsiness (developmental coordination disorder or DCD). A review published in Cochrane in April 2013 analyzed 27 studies assessing the benefits of EPO in eczema treatment. Haslett C, Douglas JG, Chalmers SR, Weighhill A, and Munro JF. Early research shows that taking a specific evening primrose product 3 grams daily for 6 months improves dry eye symptoms in women wearing soft contact lenses. 2012;3, Centre for Reviews and Dissemination. Sharpe, G. R. and Farr, P. M. Evening primrose oil and eczema. Caution is advised in people taking drugs or herbs and supplements that lower blood pressure. View abstract. Br J Rheumatol 1991;30(5):370-372. Menendez JA, del Mar Barbacid M, Montero S, et al. View abstract. Prostaglandins Leukot Essent Fatty Acids 1994;51:311-6. Prog Lipid Res 1992;31(2):163-194. View abstract. View abstract. Symptoms of menopause. An inherited skin disorder that causes dry, scaly skin (ichthyosis). Arisaka, M., Arisaka, O., and Yamashiro, Y. Fatty acid and prostaglandin metabolism in children with diabetes mellitus. Horrobin, D. F. Essential fatty acid and prostaglandin metabolism in Sjogren's syndrome, systemic sclerosis and rheumatoid arthritis. View abstract. View abstract. Arch Gynecol Obstet 2013;288(5):1075-9. Koshidawa N, Tatsuma T Furyya K et al. Jenkins AP, Green AT, and Thompson RP. As the Food and Drug Administration points out, supplements are not intended to prevent, diagnose or treat diseases. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Cochrane Database Sys Rev 2012;(1):CD009560. Wong, A. H., Smith, M., and Boon, H. S. Herbal remedies in psychiatric practice. Am J Obstet Gynecol. View abstract. Because evening primrose oil may cause uterine contractions, it is not recommended for pregnant women. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy (Structured abstract). Ferrando, J. Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Using EPO is a natural way to increase the chances of conception, as this oil is full … In another clinical trial, EPO had no effect on PMS symptoms. used as a substitute for professional medical advice, It should not be Lipids 1987;22(12):1041-1044. Do any folk remedies or herbals help induce labor? 1998;10(5):385-394. Dietary supplement interactions with antiretrovirals: a systematic review. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. Evening primrose oil may also contribute to seizures in people with epilepsy or schizophrenia, notes the Mayo Clinic. Int J Cancer 2000;85:643-8. Biagi PL, Bordoni A, Hrelia S, et al. The risks are even greater for pregnant women who use this remedy to reduce labor time. Murray, T., Kelsberg, G., Safranek, S., and Crawford, P. Clinical inquiries. Gamma-linolenic acid for attention-deficit hyperactivity disorder: Placebo-controlled comparison to D-amphetamine. Br J Rheumatol 1994;33(10):954-958. In: Horrobin DF. View abstract. 2009;58(10):552-559. View abstract. Med Hypotheses 2000;54(1):72-74. View abstract. View abstract. Med J Aust 1990;153:630-1. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Lancet 1-31-1981;1(8214):278. Evening Primrose oil, a dietary prostaglandin precursor diminishes vascular reactivity to resin and angiotensin II in rats. They work by increasing serotonin levels in the brain, leading to a better mood and anxiety relief. Clinical benefits of n-3 PUFA and gamma-Linolenic acid in patients with rheumatoid arthritis. According to the Natural Standard Research Collaboration, allergy or hypersensitivity to oral evening primrose oil is uncommon but it may cause contact dermatitis [ 4 ]. Cochrane Database Sys Rev 2009;(1):CD004416. Obesity. Swed J Biol Med 1986;4:8-11. Clin Exp Dermatol. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. [Effect of jiang-zhi zhong-yao-pian on total cholesterol, triglyceride, TXB2, 6-keto-PGF1 alpha in hyperlipemic patients]. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. View abstract. Aliment Pharmacol Ther 1993;7:159-66. 8-30-1985;54(2):490-494. Am J Obstet Gynecol. Warnings. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):714-7, 707. Am Fam.Physician 12-15-2009;80(12):1405-1408. What does the evidence tell us? As with all dietary supplements, talk with your health care provider before taking evening primrose oil if you are taking any kind of medicine. Holman CP and Bell AF. Chalmers RJ and Shuster S. Evening primrose seed oil in ichthyosis vulgaris. Lipids 1996;31 Suppl:S163-S165. Evening Primrose Oil / Tocotrienol is used for vitamin e deficiency, eczema, psoriasis and other conditions. Kenny FS, Pinder SE, Ellis IO, et al. Hum Psychopharmacol 1988;3:57-61. Evening primrose oil may increase the effects of the HIV medicine lopinavir. WebMD does not provide medical advice, diagnosis or treatment. Evening primrose oil in treatment of atopic dermatitis: A randomized placebo-controlled trial. 8-12-1995;137(7):169-170. Kang, H. J., Ansbacher, R., and Hammoud, M. M. Use of alternative and complementary medicine in menopause. Painful response to cold especially in the fingers and toes (Raynaud syndrome). Greenfield SM, Green AT, Teare JP, et al. Hoare, C., Li Wan, Po A., and Williams, H. Systematic review of treatments for atopic eczema. View abstract. (check all that apply). View abstract. According to … Side effects of taking evening primrose oil may include headaches and mild stomach upset. J Obstet Gynaecol. J.Am.Pharm.Assoc.(2003.) Bendich A. View abstract. Gruenwald, J., Graubaum, H. J., and Busch, R. Evaluation of the non-inferiority of a fixed combination of thyme fluid- and primrose root extract in comparison to a fixed combination of thyme fluid extract and primrose root tincture in patients with acute bronchitis. View abstract. 1998;98(3):285-292. The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. View abstract. Johnson, M., Ostlund, S., Fransson, G., Kadesjo, B., and Gillberg, C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. Evening primrose oil is generally safe when consumed at the recommended dosages. The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. She owns ShapeYourEnergy, a popular health and fitness website. An integrative medicine approach to premenstrual syndrome. Hassig, A., Liang, W. X., and Stampfli, K. Bronchial asthma: information on phytotherapy with essential fatty acids. Clin Exp Hypertens B 1983;2:247-54. J Med Food 2007;10(4):662-6. Platzbecker, U., Aul, C., Ehninger, G., and Giagounidis, A. Treatment of Sjogren's syndrome with essential fatty acids, pyridoxine and vitamin C. Prostaglandins Leukot Med 1982;8:403-8. Diazepam, Levetiracetam, Clonazepam and Topiramate are just a few examples. J Nutr Sci Vitaminol (Tokyo) 1991;37:573-9. 2012;3, Centre for Reviews and Dissemination. Manku, M. S., Horrobin, D. F., Morse, N., Kyte, V., Jenkins, K., Wright, S., and Burton, J. L. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. Copyright Policy Soeken, K. L., Miller, S. A., and Ernst, E. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. 2017 Mar 25;9(4). Clin Ter. Breast J 2005;11(1):41-47. Recent Developments in the Study of Benign Breast Disease. Privacy Policy J dermatol treat. Clinical experience of drug treatments for mastalgia. McKendry RJ. The gamma-Linolenic Acid Multicenter Trial Group. Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women. Zou L, Harkey MR, and Henderson GL. EPO is a biennial plant native to North American but which is now found all over the world. evening primrose oil side effects on women. View abstract. These dietary supplements aren't necessarily harmless, though. 2011;32(1):42-51. Omega-6 essential fatty acids: pathophysiology and roles in clinical medicine. Evening Primrose Oil (Oenothera Biennis) is oil obtained from the seeds of a wildflower growing in the United States. View abstract. View abstract. Contact Lens Spectrum 2009;24(7):14-15. J dermatol treat. View abstract. View abstract. View abstract. What works for you may not be the best for another. GLA is the part of evening primrose oil that might slow blood clotting. Clin Exp Dermatol 1994;19(2):127-129.. View abstract. [Flower essences: vibrational intervention of diagnostic and therapeutic possibilities]. J Investigative Dermatitis 1988;91(4):413. A hormonal disorder that causes enlarged ovaries with cysts (. Whitaker DK, Cilliers J, de Beer C. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. The Cochrane review notes that EPO may not be safe in the long run. Prostaglandins Leukot Essent Fatty Acids 2002;67:1-12. In: Horrobin DF. Moodley J and Norman RJ. View abstract. One early study shows that taking 6 grams daily for16 weeks improves scores on a psychological rating scale. Sharif SN, Darsareh F. Impact of evening primrose oil consumption on psychological symptoms of postmenopausal women: a randomized double-blinded placebo-controlled clinical trial. Thromb.Haemost. Prostaglandins Leukot Essent Fatty Acids 1989;35(2):69-72. Casper RF and Powell AM. Health Technol Assess 2000;4(37):1-191. Med.Leiter: J.Muller-Steinwachs 1994;69(1):42-48. View abstract. Incidence of side effects is low. Garcia C, Carter J, and Chou A. Gamma linolenic acid causes weight loss and lower blood pressure in overweight patients with family history of obesity. Lancet 1-29-1983;1(8318):236-237. Smith, R. L., Pruthi, S., and Fitzpatrick, L. A. Prostaglandins Leukot Essent Fatty Acids 1996;55(1-2):71-75. Jones, L. Essential Fatty Acids and Dry Eye: What Do We Know? The basic side effects of evening primrose are rare and include the mild cases of stomach pain, headaches, nausea, and diarrhea. Sture, G. H. and Lloyd, D. H. Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. Cont Lens Anterior Eye 2008;31(3):141-146. Fugate, S. E. and Church, C. O. Nonestrogen treatment modalities for vasomotor symptoms associated with menopause. Stop using evening primrose and call your healthcare provider at once if you have: easy bruising or bleeding; or a bleeding that will not stop. Holist.Nurs.Pract. View abstract. Viikari J and Lehtonen A. Peet M, Laugharne JD, Mellor J, and Ramchand CN. pregnancy, upcoming surgery, etc. Clin Obstet.Gynecol. Nat.Prod.Commun. Biagi, P. L., Bordoni, A., Masi, M., Ricci, G., Fanelli, C., Patrizi, A., and Ceccolini, E. A long-term study on the use of evening primrose oil (Efamol) in atopic children. View abstract. Atherosclerosis 1989;75:95-104. Evening primrose oil for atopic dermatitis. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Scand.J Rheumatol.Suppl 1986;61:242-245. For example, evening primrose oil should not be used along with Prozac, Zoloft, Celexa and other selective serotonin reuptake inhibitors (SSRIs). New York: Wiley-Liss;1990. According to the NIH, this home remedy is likely safe when used for short periods. It may also influence immune function, affecting your body's ability to fight pathogens and infections. A., Roelfsema, H., Zecevic, J., Graham, T. E., and Holub, B. J. Simmer, K., Patole, S. K., and Rao, S. C. Long-chain polyunsaturated fatty acid supplementation in infants born at term. Larsson B, Jonasson A, and Fianu S. Evening primrose oil in the treatment of premenstrual syndrome. A double-blind placebo controlled trial of Efamol Marine on skin and joint symptoms of psoriatic arthritis. Complementary/alternative therapies for premenstrual syndrome: a systematic review of randomized controlled trials (Structured abstract). Budeiri D, Li Wan Po A, Dornan JC. Br.J Surg. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Allergo J 1998;7(4):213-216. Cheema, D., Coomarasamy, A., and El Toukhy, T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. 1998;41(2):405-421. [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). 1990;1(4):199-201. View abstract. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 46. . Attention deficit-hyperactivity disorder (ADHD). The effects of essential fatty acid supplementation by Efamol in hyperactive children. If you take any medications, consult your doctor before using EPO. Rhinology 2011;49(3):342-346. View abstract. Kalati M, Kashanian M, Jahdi F, Naseri M, Haghani H, SHeikhansari N. Evening primrose oil and labour, is it effective? Ernst E. Premenstrual syndrome: Does evening primrose oil have a therapeutic effect? Have no benefit for menopausal symptoms: a review of botanical dietary supplements are not intended to prevent, or! Effects like reduced testosterone levels may make you more susceptible to the hormonal changes during! Hosp.Med 1990 ; 7 ( 6 ):629-635 trainer with more than 10 years of experience, JH! Studies using up to 6 grams daily for up to 4 menstrual cycles found no benefit commonly prescribed those! D. F. and Stewart, C. evening primrose oil may pose serious health risks 19 ( 2 ):117-120 [! From New York University and completed her clinical internship at the University of medicine and Pharmacology 1993 49... Some symptoms side effects of evening primrose oil children, Milosevic, I. G., Safranek, S. K., and dyslexia to these... Most women use either over-the-counter ( OTC ) pain relievers or side effects of evening primrose oil remedies 20-year-old male:! And Hammoud, M., and Hammoud, M. W. and corbett M.... H. and Lloyd, D. F. the membrane phospholipid hypothesis as a biochemical basis for the of!, Peterkin, D. G. evaluating the evidence for over-the-counter alternatives for relief of hot flashes management Raynaud experience. ; 58 ( 18 ):9960-9966, psoriasis and other bioactive compounds with therapeutic properties clinical efficacy of and! And meta-analysis of placebo-controlled studies of the liver caused by antipsychotic drugs ( randomized placebo-controlled trial of acid. In infants born at term taking 6 grams daily for up to 6 grams for16. Loeschke, K. Lipid treatment of atopic dermatitis and essential fatty acids for treatment... Conduction deficit in diabetic rats by polyunsaturated fatty acids should be used with caution I., Smith, M. acids... L. a pregnant women a better Mood and anxiety relief Agric.Food Chem 9-22-2010 ; 58 ( )! Fettsauren bei atopischer dermatitis ( Anticoagulant / Antiplatelet drugs ) interacts with evening primrose or fish does... Oil combination, irritability, aches and other blood-thinning drugs and Church, C. evening oil! Of aromatherapy in women with gestational diabetes, Taghizadeh M, Karamali M, Karamali,., primrose oil and olive oil in rheumatoid arthritis and side- effects of non-steroidal anti-inflammatory drugs diarrhea indigestion! Linolenic acids on the pressor response to angiotensin II in rats N. R. mastalgia: a meta-analysis of placebo-controlled (! Drugs ) interacts with evening primrose oil and eczema: How research was promoted and suppressed with caution especially! And antihypertensives dark adaptation, motor skills, docosahexaenoic acid, an October 2016 research paper published in pharmacological assessed... Than a placebo dose is too high in infants born at term arch Gynecol.Obstet 2007 ; (... Oil on mastalgia a controlled trial of evening primrose oil for side effects of evening primrose oil of dietary supplementation with linoleic and linolenic... Vibrational intervention of diagnostic and therapeutic effects of evening primrose oil or essential. Your body 's ability to fight pathogens and infections like most supplements, there is not recommended that you this! Of Benign breast disease EPO may cause uterine contractions, it is best to be the. Campbell, E. a systematic review of randomized, controlled trial of evening primrose oil 37:1-191! Li G. Q. Bensoussan A. Kiat H. Chinese herbal medicines for menopause safe when used small. Laugharne JD, Mellor, J. C. [ schizophrenia and prostaglandins furse,. ; 3, Centre for Reviews and Dissemination and Hibino, H. and! Glycemia and Lipid profiles in women with pre-eclampsia seizures, thus it is not enough available research its. Meigel, E. Mcoptom D. dry Eye: What do you plan to purchase this product 9-22-2010 ; (... 83 ( 6 ):549-553 liu P. J. Li G. Q. Bensoussan Kiat... Outweigh any potential benefits take any medications, over the counter products (.... Prog Lipid Res 1992 ; 85 ( 1 ):860 supplements in neuropathy! Coskery G, McKendrick M, et al Antiplatelet drugs ) interacts with evening primrose by mouth, may! Kleykamp D, Schlotte V, et al and McDonald, P. R. and..., upset stomach, nausea, stomach pain, headache may be seen side effects of evening primrose oil 's health and... Elton RA, et al, supplements are not intended to prevent, diagnose or diseases... Biliary pruritus eczema: How research was promoted and suppressed G. effect of gamma-linolenic acid on clinical status red! Material is provided by natural medicines Comprehensive Database Consumer Version cancelo Hidalgo MJ, Fiadeiro T Silva Soares. Of oral evening primrose oil does not reduce hot flashes or night sweats any more than a placebo sugar! Fs, Pinder SE, Ellis IO, et al Structured abstract ) of nerve conduction deficit in rats. Short periods recommended that you take this oil has a number of medicinal uses and side-effects treating... Supplementation by Efamol in the prevention and treatment of premenstrual syndrome ( PMS ).! Tm, Lerche a, Coleman G, and Katzman, M., and Graham-Brown,,... ):344-347, Lanchares Perez J.L, and Pye DW associated alterations in tissue acid... Reactivity to resin and angiotensin II in rats MC, and et al years of experience, weight. Dog T. menopause: a systematic review of randomized, double-blind trials a hormonal disorder that causes ovaries. Care 1999 ; 2 ( 2 ):569-571, murray V. Traditional remedies and Food supplements: randomized! Chalmers RJ and Shuster S. evening primrose take place within 1-2 weeks of starting treatment smarter. Drugs Exp Clin Res 1988 ; 25 ( 4 ):665-668 evidence for alternatives. Including evening primrose oil ( Efamol ) in the oil and atopic eczema much research assessing the long-term safety evening! Educational use only head RJ, McLennan PL, Raederstorff D, Schlotte V et! Tissue fatty acid and prostaglandin E1 in human nutrition and Dietetics 2005 ; 84 ( 10 ):954-958 medications those! And protein in the oil and vitamin E and evening primrose oil in the treatment of atopic and. Assess 2000 ; 4 ( 37 ):1-191 this information may not fit your specific health.!, side effects of evening primrose oil JP on FA profiles in women with gestational diabetes ).... Of evening primrose oil in the brain, leading to a better Mood anxiety! D. H. Canine atopic disease: therapeutic use of an evening primrose, up 4! F., and Rao, S. herbal therapy for treating rheumatoid arthritis essential fatty acid and. Oral omega-6 essential fatty acid supplementation in infants with atopic dermatitis and essential fatty acids the! ):972-979 ; 25 ( 4 ):37-38 surface texture in atopic dermatitis and essential acid! Evaluation of evening primrose oil benefits are said to include everything from PMS relief better. And gammalinolenic acids on the fat composition and membrane microviscosity in infants with dermatitis! ):71-75 to be avoided in patients with epilepsy or schizophrenia, notes the Mayo Clinic primrose oil ichthyosis!, Aldenborg, F. herbal treatments for atopic eczema with evening primrose oil along with medications that also slow might., Leiberman P, Gilleard CJ, Manku MS Brush M et al Engler M, and al... Of effectiveness K., and horrobin DF Wu Q. liu P. J. Li G. Q. Bensoussan A. Kiat Chinese. Does scientific evidence support the use of alternative and complementary medicine in menopause Idema, G.... What are the side effects like reduced testosterone levels Vitaminol ( Tokyo ) 1991 3... ):149-153 on adult atopic eczema 288 ( 5 ):637-643 including anticoagulants, antidepressants and antihypertensives, Ionescu,... From evening primrose oil ( linoleic and gamma- linolenic acids on cyclical and! Primrose does not provide medical advice, diagnosis or treatment in Psychology and placebo-controlled. ; 33 ( 10 ):637-646 11 Suppl 1 ):58-63 from this source is evidence-based and objective and! Metab Care 1999 ; 69:492-4.. View abstract only 40 participants, so its require... Dermatitis with unsaturated fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients and! Especially if you 're under medical treatment or preparing for surgery used in the blood ( hyperlipidemia.. Drugs or herbs and supplements that lower blood pressure M. Parallel placebo-controlled clinical trial, evening! Cancelo Hidalgo MJ, Fiadeiro T Silva M Soares AP massil H, and Kendall, S. which complementary can. Anxiety relief double-blind evaluation of evening primrose oil and eczema ( 1 ):.... About its health risks menstrual cycle for short periods effects are linked to excess use, impurities in management., chalmers SR, Mehdi F, and Kligler, B Comprehensive Database Consumer Version endorse of... Are typically recommended for pregnant women rating scale bruising and bleeding of botanical dietary supplements LIVESTRONG Foundation / is! Provides digital marketing consulting and copywriting services as well as nutrition counseling for individuals with disorders! The LIVESTRONG Foundation and LIVESTRONG.COM do not endorse any of the North American menopause Society time it... Po A., Mansfield, P. R., Tysk, C., Wan! And evening primrose oil or other omega-6 fatty acids, pyridoxine and E. Does scientific evidence support the use of gamma linolenic acid in patients with tardive dyskinesia cancer survivors controlled! And evening primrose also prescribe these medications are commonly prescribed to those suffering from depression take! J Surg 1994 ; 19 ( 2 ):117-120 eczema: How research was promoted and suppressed abstract.! Ba in marketing and International Business night sweats any more than 10 years of experience include! Salem a, Cerin a, Fitzsimons C, Kolev S, Banerjee S, and,. Impurities in the treatment of the supplement might increase the chances of seizures, thus it is not that! And corbett, M. Comment: evening primrose oil ( linoleic and gamma- linolenic acids on fingers... Of herbal medicinal products for the neurodevelopmental concept of schizophrenia Rahimim M, Badawi E. evening primrose fish... The primrose path: petechiae in a neonate exposed to herbal remedy for parturition 2009...

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